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INS-1 832/3 and MIN6B1 cells were stimulated in serum-free media plus 3 mM glucose and IBMX as indicated, with results expressed relative to time-point-specific IBMX-only baseline
Acknowledgments The authors extend their gratitude to the Clinical Translation Engineering Research Center for Digital Medicine of Guangxi Zhuang Autonomous Region for their invaluable support
33 NACs clinical benefits may stem from multiple mechanisms besides GSH replenishment, including ( i ) indirect antioxidant effects, ( ii ) provision of hydrogen sulfide (H 2 S) and sulfane sulfur with anti-inflammatory properties, 14,19,37,38 or ( iii ) an impact on NO regulation